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KMID : 1039120170060020160
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Clinical and Experimental Vaccine Research
2017 Volume.6 No. 2 p.160 ~ p.163
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Application of aptamers for assessment of vaccine efficacy
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Yoon Soo-Young
Gee Grace
Hong Kee-Jong
Seo Sang-Hwan
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Abstract
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Assessing antigen concentration of vaccine is essential step in determining the quality of the vaccine prior to vaccination. After vaccination, vaccine-induced antibody titer should also be measured to verify the vaccine efficacy. Since conventional assay used for vaccine concentrations and induced Ab-titers is antibody-based enzyme-linked immunosorbent assay, the assay inevitably brings drawbacks of antibody such as high cost for production, limited stability, and inconsistent quality between lot-to-lots. Aptamer is single-stranded nucleic acid having three-dimensional structure and has features overcoming limitations of antibody. This review will briefly introduce the features of aptamer and potential of aptamer-based system for evaluation of vaccine efficacy.
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KEYWORD
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Aptamers, Vaccines, Enzyme-linked immunosorbent assay, Antigens, Antibodies
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